Name: Thalidomide-5-propargyne-NH2 hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT213124272
Cas No:2490402-62-3
常用名:Thalidomide-5-propargyne-NH2 hydrochloride
常用名:Thalidomide-5-propargyne-NH2 hydrochloride
别名:Thalidomide-5-propargyne-NH2 hydrochloride
别名:Thalidomide-5-propargyne-NH2 hydrochloride
IUPAC:5-(3-aminoprop-1-yn-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride
IUPAC:5-(3-aminoprop-1-yn-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride
InChI key:XOXKGOUHXULLNX-UHFFFAOYSA-N

分子式:C16H14ClN3O4
分子量:347.76
氢键供体数 (HBD):2
氢键受体数 (HBA):5
LogP:-0.56
SMILES:Cl.NCC#Cc1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1
SMILES:Cl.NCC#Cc1ccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2c1

Thalidomide-5-propargyne-NH2 hydrochloride is a cereblon ligand derived from Thalidomide that is utilized in the recruitment of CRBN protein. It can be linked to the protein ligand through a linker to produce PROTACs, which are compounds used for protein degradation.

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