Name: Bromodomain inhibitor-10
Rating: 5 (10 reviews)

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HIT ID:HIT213135644
Cas No:1870849-58-3
常用名:Bromodomain inhibitor-10
IUPAC:N-(4-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-(morpholin-4-yl)pyridine-3-carboxamide
IUPAC:N-(4-methyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-(morpholin-4-yl)pyridine-3-carboxamide
InChI key:OSFZBGUNRGOXKG-UHFFFAOYSA-N

分子式:C20H20N4O3
分子量:364.405
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1cc(=O)[nH]c2ccc(NC(=O)c3cccnc3N3CCOCC3)cc12
SMILES:Cc1cc(=O)[nH]c2ccc(NC(=O)c3cccnc3N3CCOCC3)cc12

Bromodomain inhibitor-10 (compound 128) is a highly potent inhibitor of bromodomain activity. It exhibits strong binding affinity with K d values of 15.0 nM and 2500 nM for BRD4-1 and BRD4-2, respectively. Furthermore, Bromodomain inhibitor-10 effectively inhibits the production of IL12p40 [1].

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