Name: (±)-N-desmethyl Venlafaxine hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT213660412
Cas No:93413-90-2
常用名:(±)-N-desmethyl Venlafaxine hydrochloride
常用名:(±)-N-desmethyl Venlafaxine hydrochloride
别名:Wy 45494
IUPAC:1-[1-(4-methoxyphenyl)-2-(methylamino)ethyl]cyclohexan-1-ol hydrochloride
IUPAC:1-[1-(4-methoxyphenyl)-2-(methylamino)ethyl]cyclohexan-1-ol hydrochloride
InChI key:HWPAFKGYJZARRM-UHFFFAOYSA-N

分子式:C16H26ClNO2
分子量:299.84
氢键供体数 (HBD):2
氢键受体数 (HBA):3
LogP:2.689
SMILES:Cl.CNCC(c1ccc(OC)cc1)C1(O)CCCCC1
SMILES:Cl.CNCC(c1ccc(OC)cc1)C1(O)CCCCC1

(±)-N-desmethyl Venlafaxine, a minor active metabolite of venlafaxine, serves as a selective norepinephrine and serotonin reuptake inhibitor (SNRI). Generated through the metabolization by the cytochrome P450 (CYP) isoform CYP3A4, it exhibits reuptake inhibition of norepinephrine and serotonin in rat synaptosome preparations, demonstrated by IC50 values of 4.7 and 1.6 µM, respectively. Clinically, it has been shown to counteract reserpine-induced hypothermia in mice, displaying efficacy at a minimum effective dose (MED) of 10 mg/kg.

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