Name: 5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate
Rating: 5 (10 reviews)

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HIT ID:HIT213828124
Cas No:127770-45-0
常用名:5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate
常用名:5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate
IUPAC:3',6'-bis(acetyloxy)-2',7'-dichloro-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acid; 3',6'-bis(acetyloxy)-2',7'-dichloro-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-6-carboxylic acid
IUPAC:3',6'-bis(acetyloxy)-2',7'-dichloro-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acid; 3',6'-bis(acetyloxy)-2',7'-dichloro-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-6-carboxylic acid
InChI key:LZMPJBOMBCYYMP-UHFFFAOYSA-N

分子式:C50H28Cl4O18
分子量:1058.56
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(=O)Oc1cc2Oc3cc(OC(C)=O)c(Cl)cc3C3(OC(=O)c4cc(ccc34)C(O)=O)c2cc1Cl.CC(=O)Oc1cc2Oc3cc(OC(C)=O)c(Cl)cc3C3(OC(=O)c4ccc(cc34)C(O)=O)c2cc1Cl
SMILES:CC(=O)Oc1cc2Oc3cc(OC(C)=O)c(Cl)cc3C3(OC(=O)c4cc(ccc34)C(O)=O)c2cc1Cl.CC(=O)Oc1cc2Oc3cc(OC(C)=O)c(Cl)cc3C3(OC(=O)c4ccc(cc34)C(O)=O)c2cc1Cl

5(6)-Carboxy-2’,7’-dichlorofluorescein diacetate is an oxidant-sensitive and cell-permeable fluorescent probe.1Base hydrolysis of the ester bonds by intracellular esterases releases the acetate groups and the resulting compound, 5(6)-carboxy-2’,7’,-dichlorofluorescein, is oxidized by reactive oxygen species (ROS) and nitric oxide (NO) and displays excitation/emission maxima of 504 and 530 nm, respectively, which can be quantified as a measure of oxidant production.

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