Name: Sar-[D-Phe8]-des-Arg9-Bradykinin acetate
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HIT ID:HIT213840133
Cas No:2918768-32-6
常用名:Sar-[D-Phe8]-des-Arg9-Bradykinin acetate
常用名:Sar-[D-Phe8]-des-Arg9-Bradykinin acetate
别名:Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base)
别名:Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base)
IUPAC:(2R)-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{[(2S)-1-[(2S)-1-[(2S)-5-[(diaminomethylidene)amino]-2-[2-(methylamino)acetamido]pentanoyl]pyrrolidine-2-carbonyl]pyrrolidin-2-yl]formamido}acetamido)-3-phenylpropanamido]-3-hydroxypropanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoic acid; acetic acid
IUPAC:(2R)-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{[(2S)-1-[(2S)-1-[(2S)-5-[(diaminomethylidene)amino]-2-[2-(methylamino)acetamido]pentanoyl]pyrrolidine-2-carbonyl]pyrrolidin-2-yl]formamido}acetamido)-3-phenylpropanamido]-3-hydroxypropanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanoic acid; acetic acid
InChI key:VHFRYBVXBZJDKE-PBFNVPQASA-N

分子式:C49H70N12O13
分子量:1035.17
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[#6]-[#6](-[#8])=O.[#6]-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](-[#8])=O
SMILES:[#6]-[#6](-[#8])=O.[#6]-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](-[#8])=O

Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base) 是一种有效的选择性缓激肽 B1 受体激动剂（兔主动脉中的 EC50 = 9.02 nM），对氨肽酶、激肽酶 I 和 II (ACE) 以及中性内肽酶切割具有抗性。在体内表现出降血压和血管生成活性。

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