Name: Bavdegalutamide
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT213840187
Cas No:148890-53-3;2222112-77-6
常用名:Bavdegalutamide
别名:ARV-110
IUPAC:6-[4-({4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}methyl)piperidin-1-yl]-N-[(1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl]pyridazine-3-carboxamide
IUPAC:6-[4-({4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}methyl)piperidin-1-yl]-N-[(1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl]pyridazine-3-carboxamide
InChI key:CLCTZVRHDOAUGJ-SYVGMNBRSA-N

分子式:C41H43ClFN9O6
分子量:812.3
氢键供体数 (HBD):2
氢键受体数 (HBA):12
LogP:4,263
SMILES:Fc1cc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2cc1N1CCN(CC2CCN(CC2)c2ccc(nn2)C(=O)N[C@H]2CC[C@@H](CC2)Oc2ccc(C#N)c(Cl)c2)CC1 |wU:43.51,wD:40.44,(5.2,4.38,;3.86,3.61,;2.53,4.38,;1.2,3.61,;-.27,4.09,;-.74,5.55,;-1.17,2.84,;-2.71,2.84,;-3.48,1.51,;-5.02,1.51,;-5.79,2.84,;-7.33,2.84,;-5.02,4.18,;-3.48,4.18,;-2.71,5.51,;-.27,1.6,;-.74,.13,;1.2,2.07,;2.53,1.3,;3.86,2.07,;5.2,1.3,;5.2,-.24,;6.53,-1.01,;7.87,-.24,;9.2,-1.01,;10.53,-.24,;11.87,-1.01,;13.2,-.24,;13.2,1.3,;11.87,2.07,;10.53,1.3,;14.53,2.07,;15.87,1.3,;17.2,2.07,;17.2,3.61,;15.87,4.38,;14.53,3.61,;18.53,4.38,;18.53,5.92,;19.87,3.61,;21.2,4.38,;22.54,3.61,;23.87,4.38,;23.87,5.92,;22.54,6.69,;21.2,5.92,;25.2,6.69,;25.2,8.23,;23.87,9,;23.87,10.54,;25.2,11.31,;25.2,12.85,;25.2,14.39,;26.54,10.54,;27.87,11.31,;26.54,9,;7.87,1.3,;6.53,2.07,)|
SMILES:Fc1cc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2cc1N1CCN(CC2CCN(CC2)c2ccc(nn2)C(=O)N[C@H]2CC[C@@H](CC2)Oc2ccc(C#N)c(Cl)c2)CC1 |wU:43.51,wD:40.44,(5.2,4.38,;3.86,3.61,;2.53,4.38,;1.2,3.61,;-.27,4.09,;-.74,5.55,;-1.17,2.84,;-2.71,2.84,;-3.48,1.51,;-5.02,1.51,;-5.79,2.84,;-7.33,2.84,;-5.02,4.18,;-3.48,4.18,;-2.71,5.51,;-.27,1.6,;-.74,.13,;1.2,2.07,;2.53,1.3,;3.86,2.07,;5.2,1.3,;5.2,-.24,;6.53,-1.01,;7.87,-.24,;9.2,-1.01,;10.53,-.24,;11.87,-1.01,;13.2,-.24,;13.2,1.3,;11.87,2.07,;10.53,1.3,;14.53,2.07,;15.87,1.3,;17.2,2.07,;17.2,3.61,;15.87,4.38,;14.53,3.61,;18.53,4.38,;18.53,5.92,;19.87,3.61,;21.2,4.38,;22.54,3.61,;23.87,4.38,;23.87,5.92,;22.54,6.69,;21.2,5.92,;25.2,6.69,;25.2,8.23,;23.87,9,;23.87,10.54,;25.2,11.31,;25.2,12.85,;25.2,14.39,;26.54,10.54,;27.87,11.31,;26.54,9,;7.87,1.3,;6.53,2.07,)|

Bavdegalutamide (ARV-110)是一种口服蛋白质降解剂，特异性结合 AR 并介导其降解。Bavdegalutamide可以降解临床相关的突变 AR 蛋白，在高雄激素环境中保持活性并具有可接受的安全性。

市场产品/服务共显示2个结果

供应商
TargetMolSC
规格
货期
1-3天
纯度
99.44%
¥ 738.00
1
供应商
PharmaBlockBB
规格
货期
4-7周
纯度
-
待询
1

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