Name: (+)-Acuminatin
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT213884215
Cas No:41744-39-2
常用名:(+)-Acuminatin
别名:Acuminatin
IUPAC:(2R,3R)-2-(3,4-dimethoxyphenyl)-7-methoxy-3-methyl-5-[(1E)-prop-1-en-1-yl]-2,3-dihydro-1-benzofuran
IUPAC:(2R,3R)-2-(3,4-dimethoxyphenyl)-7-methoxy-3-methyl-5-[(1E)-prop-1-en-1-yl]-2,3-dihydro-1-benzofuran
InChI key:ITFKWUHXYCXXFF-XSOBDOKWSA-N

分子式:C21H24O4
分子量:340.419
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1cc(\C=C\C)cc2[C@@H](C)[C@@H](Oc12)c1ccc(OC)c(OC)c1
SMILES:COc1cc(\C=C\C)cc2[C@@H](C)[C@@H](Oc12)c1ccc(OC)c(OC)c1

(+)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity against platelet aggregation with IC50 values of 108.5 and 90.02 uM, respectively. (+)-Acuminatin, and machilin G show dose-dependent potent inhibitory activities against PLCgamma1 in vitro with IC50 values ranging from 8.8 to 26.0 microM, the inhibition of PLCgamma1 may be an important mechanism for an antiproliferative effect on the human cancer cells, therefore, these inhibitors may be utilized as cancer chemotherapeutic and chemopreventive agents.

市场产品/服务共显示2个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~