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  3. HIT213884572
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HIT213884572
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HIT213884572
  • HIT ID:HIT213884572
  • Cas No:56365-38-9
  • 常用名:Capillarisin
  • IUPAC:5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-chromen-4-one
    IUPAC:5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-chromen-4-one
  • InChI key:NTKNGUAZSFAKEE-UHFFFAOYSA-N
  • 分子式:C16H12O7
  • 分子量:316.265
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COc1c(O)cc2oc(Oc3ccc(O)cc3)cc(=O)c2c1O
    SMILES:COc1c(O)cc2oc(Oc3ccc(O)cc3)cc(=O)c2c1O
  • Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with G0/G1-phase cell cycle arrest and loss in mitochondrial membrane potential.Capillarisin has anti-inflammatory activity, can inhibit LPS-induced inflammation by blocking TLR4-mediated NF-κB and MAPKs activation in BV2 microglia. Capillarisin possesses promising anti-hyperalgesic and anti-allodynic effects through the inhibition of various inflammatory pain signaling.
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  • 供应商
    TargetMolSC
    规格
    货期
    纯度
    -
    ¥ 65,000.00
    1

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