Name: 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
Rating: 5 (10 reviews)

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HIT ID:HIT213884582
Cas No:125537-92-0
常用名:3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
常用名:3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
IUPAC:2-(3,5-dihydroxy-4-methoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one
IUPAC:2-(3,5-dihydroxy-4-methoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one
InChI key:KPONYCCDEVQZMR-UHFFFAOYSA-N

分子式:C17H14O8
分子量:346.291
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1c(O)cc(cc1O)-c1cc(=O)c2c(O)c(OC)c(O)cc2o1
SMILES:COc1c(O)cc(cc1O)-c1cc(=O)c2c(O)c(OC)c(O)cc2o1

5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptase. It exhibits cytotoxic activity against P-388 cell lines, it can inhibit DNA topoisomerase IIα activity, which may be responsible for the observed cytotoxicity.

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