15-Methoxypinusolidic acid | CAS 769928-72-5

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HIT ID:HIT213884647
Cas No:769928-72-5
常用名:15-Methoxypinusolidic acid
IUPAC:(1S,4aR,5S,8aR)-5-[2-(5-methoxy-2-oxo-2,5-dihydrofuran-3-yl)ethyl]-1,4a-dimethyl-6-methylidene-decahydronaphthalene-1-carboxylic acid
IUPAC:(1S,4aR,5S,8aR)-5-[2-(5-methoxy-2-oxo-2,5-dihydrofuran-3-yl)ethyl]-1,4a-dimethyl-6-methylidene-decahydronaphthalene-1-carboxylic acid
InChI key:OREKSZUASHFFQA-OBNOUSFBSA-N

分子式:C21H30O5
分子量:362.466
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COC1OC(=O)C(CC[C@H]2C(=C)CC[C@@H]3[C@]2(C)CCC[C@]3(C)C(O)=O)=C1 |c:26|
SMILES:COC1OC(=O)C(CC[C@H]2C(=C)CC[C@@H]3[C@]2(C)CCC[C@]3(C)C(O)=O)=C1 |c:26|

15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methoxypinusolidic acid suppresses adipocyte differentiation through the inhibition of PPARgamma-dependent adipogenic gene expression.15-Methoxypinusolidic acid attenuates glutamate-induced excitotoxicity via stabilization of [Ca2+]i homeostasis and suppression of oxidative stress possibly through the actions on the NMDA receptors.15-Methoxypinusolidic acid induced apoptosis in murine microglial cells, presumably via inhibition of the cell cycle progression.

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