Name: 4,9-Dihydroxy-alpha-lapachone
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT213884812
Cas No:56473-67-7
常用名:4,9-Dihydroxy-alpha-lapachone
IUPAC:(4S)-4,9-dihydroxy-2,2-dimethyl-2H,3H,4H,5H,10H-naphtho[2,3-b]pyran-5,10-dione
IUPAC:(4S)-4,9-dihydroxy-2,2-dimethyl-2H,3H,4H,5H,10H-naphtho[2,3-b]pyran-5,10-dione
InChI key:KGIQEUTUJPXAKQ-VIFPVBQESA-N

分子式:C15H14O5
分子量:274.272
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC1(C)C[C@H](O)C2=C(O1)C(=O)c1c(O)cccc1C2=O |c:6|
SMILES:CC1(C)C[C@H](O)C2=C(O1)C(=O)c1c(O)cccc1C2=O |c:6|

4,9-Dihydroxy-alpha-lapachone has antitumor-promoting effects, it exhibits significant inhibitory activity against 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells. 4,9-Dihydroxy-alpha-lapachone exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC(50) value of 2.73 microM.

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