Name: Shizukaol D
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT213884865
Cas No:142279-42-3
常用名:Shizukaol D
IUPAC:methyl 2-[(1R,2S,8S,9R,10S,12R,13S,14S,17S,19R,20S,21R,23Z)-9-[(acetyloxy)methyl]-21-hydroxy-5-(hydroxymethyl)-13,20-dimethyl-4,22-dioxo-3-oxaoctacyclo[14.7.1.0^{2,6}.0^{2,14}.0^{8,13}.0^{10,12}.0^{17,19}.0^{20,24}]tetracosa-5,16(24)-dien-23-ylidene]propanoate
IUPAC:methyl 2-[(1R,2S,8S,9R,10S,12R,13S,14S,17S,19R,20S,21R,23Z)-9-[(acetyloxy)methyl]-21-hydroxy-5-(hydroxymethyl)-13,20-dimethyl-4,22-dioxo-3-oxaoctacyclo[14.7.1.0^{2,6}.0^{2,14}.0^{8,13}.0^{10,12}.0^{17,19}.0^{20,24}]tetracosa-5,16(24)-dien-23-ylidene]propanoate
InChI key:UEHIWILSQZCXQY-LWKKLXHHSA-N

分子式:C33H38O9
分子量:578.658
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COC(=O)C(\C)=C1\[C@H]2C3=C(C[C@H]4[C@@]5(C)[C@@H]6C[C@@H]6[C@@H](COC(C)=O)[C@@H]5CC5=C(CO)C(=O)O[C@]245)[C@H]2C[C@H]2[C@]3(C)[C@@H](O)C1=O |c:8,27|
SMILES:COC(=O)C(\C)=C1\[C@H]2C3=C(C[C@H]4[C@@]5(C)[C@@H]6C[C@@H]6[C@@H](COC(C)=O)[C@@H]5CC5=C(CO)C(=O)O[C@]245)[C@H]2C[C@H]2[C@]3(C)[C@@H](O)C1=O |c:8,27|

Shizukaol D exerts a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner by modulating wnt signalling pathway. Shizukaol D may be used to treat metabolic syndrome, it induces mitochondrial dysfunction by depolarizing the mitochondrial membrane and suppressing energy production, which may result in AMPK activation.

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