Name: Isolupalbigenin
Rating: 5 (10 reviews)

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HIT ID:HIT213885041
Cas No:162616-70-8
常用名:Isolupalbigenin
IUPAC:5,7-dihydroxy-3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
IUPAC:5,7-dihydroxy-3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
InChI key:FXJPTJQFJYNFKC-UHFFFAOYSA-N

分子式:C25H26O5
分子量:406.478
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:6.534
SMILES:[#6]\[#6](-[#6])=[#6]\[#6]-c1cc(ccc1-[#8])-c1coc2c(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])cc(-[#8])c2c1=O
SMILES:[#6]\[#6](-[#6])=[#6]\[#6]-c1cc(ccc1-[#8])-c1coc2c(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])cc(-[#8])c2c1=O

Isolupalbigenin shows promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM), it also shows in vitro inhibitory activity toward human glyoxalase I. Isolupalbigenin shows two different antibacterial activities against MRSA: direct growth inhibition and intensification of methicillin sensitivity, it could lead to the development of compounds for new approaches against MRSA infection.

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