Name: Voleneol
Rating: 5 (10 reviews)

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HIT ID:HIT213885050
Cas No:70389-88-7
常用名:Voleneol
IUPAC:(1S,2S,4aR,5R,8aS)-4a-methyl-8-methylidene-2-(propan-2-yl)-decahydronaphthalene-1,5-diol
IUPAC:(1S,2S,4aR,5R,8aS)-4a-methyl-8-methylidene-2-(propan-2-yl)-decahydronaphthalene-1,5-diol
InChI key:WKKJGHCXVKEJNU-QRTUWBSPSA-N

分子式:C15H26O2
分子量:238.371
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)[C@@H]1CC[C@@]2(C)[C@H](O)CCC(=C)[C@@H]2[C@H]1O
SMILES:CC(C)[C@@H]1CC[C@@]2(C)[C@H](O)CCC(=C)[C@@H]2[C@H]1O

1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependently suppress the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2),suggest thats DE may be a good candidate to regulate LPS-induced inflammatory response.

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