Name: Daurinoline
Rating: 5 (10 reviews)

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HIT ID:HIT213885311
Cas No:2831-75-6
常用名:Daurinoline
别名:蝙蝠葛诺林碱
IUPAC:(1R)-1-{[4-(5-{[(1R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-2-hydroxyphenoxy)phenyl]methyl}-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-6-ol
IUPAC:(1R)-1-{[4-(5-{[(1R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-2-hydroxyphenoxy)phenyl]methyl}-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-6-ol
InChI key:APIHNXDZCYDPTF-FIRIVFDPSA-N

分子式:C37H42N2O6
分子量:610.751
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1cc2[C@@H](Cc3ccc(Oc4cc(C[C@H]5N(C)CCc6cc(OC)c(OC)cc56)ccc4O)cc3)N(C)CCc2cc1O
SMILES:COc1cc2[C@@H](Cc3ccc(Oc4cc(C[C@H]5N(C)CCc6cc(OC)c(OC)cc56)ccc4O)cc3)N(C)CCc2cc1O

Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function on microcirculation of cerebral pia mater, which may be beneficial to relieve cerebral ischemic injury. Daurinoline could significantly reverse noradrenaline induced constriction of pial arterioles and venules, and increase the number of blood vessels which were decreased by noradrenaline.

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