Name: (3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid
Rating: 5 (10 reviews)

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HIT ID:HIT213885460
Cas No:1961358-02-0
常用名:(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid
常用名:(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid
IUPAC:(5Z)-6-[(1R,3aR,4S,5aR,7S,9aS,11S,11aR)-4,7,11-trihydroxy-3a,6,6,9a,11a-pentamethyl-3,10-dioxo-1H,2H,3H,3aH,4H,5H,5aH,6H,7H,8H,9H,9aH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-methyl-4-oxohept-5-enoic acid
IUPAC:(5Z)-6-[(1R,3aR,4S,5aR,7S,9aS,11S,11aR)-4,7,11-trihydroxy-3a,6,6,9a,11a-pentamethyl-3,10-dioxo-1H,2H,3H,3aH,4H,5H,5aH,6H,7H,8H,9H,9aH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-methyl-4-oxohept-5-enoic acid
InChI key:YPBOVCHDEBYUDW-HRLXDLDBSA-N

分子式:C30H42O8
分子量:530.658
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(CC(=O)\C=C(\C)[C@H]1CC(=O)[C@@]2(C)C3=C(C(=O)[C@@H](O)[C@]12C)[C@@]1(C)CC[C@H](O)C(C)(C)[C@@H]1C[C@@H]3O)C(O)=O |c:14|
SMILES:CC(CC(=O)\C=C(\C)[C@H]1CC(=O)[C@@]2(C)C3=C(C(=O)[C@@H](O)[C@]12C)[C@@]1(C)CC[C@H](O)C(C)(C)[C@@H]1C[C@@H]3O)C(O)=O |c:14|

(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid, a lanostane triterpenoid, demonstrates significant inhibitory effects on nitric oxide (NO) production in BV-2 microglia cells induced by n LPS, with an IC50 value of 9.55 uM. Moreover, this compound possesses anti-inflammatory properties.

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