Name: Griffipavixanthone
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT213885493
Cas No:219649-95-3
常用名:Griffipavixanthone
IUPAC:1-[(8R,8aR,12aS)-1,3,6,7-tetrahydroxy-9,9,11-trimethyl-13-oxo-8H,8aH,9H,10H,12aH,13H-indeno[1,2-a]xanthen-8-yl]-3,4,6,8-tetrahydroxy-9H-xanthen-9-one
IUPAC:1-[(8R,8aR,12aS)-1,3,6,7-tetrahydroxy-9,9,11-trimethyl-13-oxo-8H,8aH,9H,10H,12aH,13H-indeno[1,2-a]xanthen-8-yl]-3,4,6,8-tetrahydroxy-9H-xanthen-9-one
InChI key:KAPVRSRPLHVWCH-CVKDPSGVSA-N

分子式:C36H28O12
分子量:652.608
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC1=C[C@H]2[C@H]([C@@H](c3c2c2c(oc4cc(O)cc(O)c4c2=O)c(O)c3O)c2cc(O)c(O)c3oc4cc(O)cc(O)c4c(=O)c23)C(C)(C)C1 |t:1|
SMILES:CC1=C[C@H]2[C@H]([C@@H](c3c2c2c(oc4cc(O)cc(O)c4c2=O)c(O)c3O)c2cc(O)c(O)c3oc4cc(O)cc(O)c4c(=O)c23)C(C)(C)C1 |t:1|

Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. It can inhibit tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer.

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