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- HIT ID:HIT213885593
- Cas No:22804-49-5
- InChI key:FFVKXGZKJBHJMS-UHFFFAOYSA-N
- 分子式:C16H14O6
- 分子量:302.282
- 氢键供体数 (HBD):
- 氢键受体数 (HBA):
- LogP:
- 1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. HM-1,at the concentration of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-culture system with mouse osteoblastic calvarial cells and bone marrow cells; it also can protect mice from the acute lung injury induced by ipopolysaccharide (LPS), which is relative to the increasing of IκB-α protein expression and the suppressing of inducible nitric oxide synthase and cyclooxygenase-Ⅱ protein expression.
市场产品/服务共显示2个结果
- 供应商TargetMol规格货期纯度-¥ 10,500.001
- 供应商AnyMole规格货期纯度-¥ 3,400.001
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