Name: Lysicamine
Rating: 5 (10 reviews)

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HIT ID:HIT213885912
Cas No:15444-20-9
常用名:Lysicamine
IUPAC:15,16-dimethoxy-10-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(16),2,4,6,9(17),10,12,14-octaen-8-one
IUPAC:15,16-dimethoxy-10-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(16),2,4,6,9(17),10,12,14-octaen-8-one
InChI key:DPBMWJXWUINLQT-UHFFFAOYSA-N

分子式:C18H13NO3
分子量:291.306
氢键供体数 (HBD):
氢键受体数 (HBA):2
LogP:3.35
SMILES:COc1cc2ccnc3C(=O)c4ccccc4-c(c1OC)c23
SMILES:COc1cc2ccnc3C(=O)c4ccccc4-c(c1OC)c23

Lysicamine shows significant antioxidant capacity in the ORAC(FL) assay and it is active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1). Lysicamine has antimicrobial and anti-inflammation activity, the minimum inhibitory concentrations of the pour component (Streptococcus mutans, Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans and Candida albicans.) is less than 5mg/ml for all four microorganisms and the minimum concentration with anti-inflammation is 0.2mg/ml for both IL-8 and IL-6. Lysicamine has antileishmanial activity. It can significantly inhibit the proliferation of melanoma cells, it has antioxidative activity and chemopreventive activity in skin melanoma cells.

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