Name: Murrangatin
Rating: 5 (10 reviews)

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HIT ID:HIT213886039
Cas No:37126-91-3;88546-96-7
常用名:Murrangatin
IUPAC:8-[(1R,2S)-1,2-dihydroxy-3-methylbut-3-en-1-yl]-7-methoxy-2H-chromen-2-one
IUPAC:8-[(1R,2S)-1,2-dihydroxy-3-methylbut-3-en-1-yl]-7-methoxy-2H-chromen-2-one
InChI key:DKEANOQWICTXTP-UONOGXRCSA-N

分子式:C15H16O5
分子量:276.288
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1ccc2ccc(=O)oc2c1[C@@H](O)[C@@H](O)C(C)=C
SMILES:COc1ccc2ccc(=O)oc2c1[C@@H](O)[C@@H](O)C(C)=C

Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100. Murrangatin exhibits antibacterial activity against P. gingivalis (ATCC 33277). Murrangatin also shows soluble epoxide hydrolase inhibitory activity with IC50 values 13.9±6.5uM. Murrangatin and murracarpin may be a new backbone for developing inhibitors of cyclooxygenase 2, they show chondroprotective activity by downregulation of interleukin-1β, tumor necrosis factorα, prostaglandins E2,and matrix metalloproteinases -13, and both of them may be a new backbone for developing inhibitors of cyclooxygenase 2.

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