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  3. HIT213886366
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HIT213886366
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HIT213886366
  • HIT ID:HIT213886366
  • Cas No:85122-21-0
  • 常用名:2-Methoxystypandrone
  • IUPAC:6-acetyl-5-hydroxy-2-methoxy-7-methyl-1,4-dihydronaphthalene-1,4-dione
    IUPAC:6-acetyl-5-hydroxy-2-methoxy-7-methyl-1,4-dihydronaphthalene-1,4-dione
  • InChI key:SSHJHOVVYKCJJI-UHFFFAOYSA-N
  • 分子式:C14H12O5
  • 分子量:260.245
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COC1=CC(=O)c2c(O)c(C(C)=O)c(C)cc2C1=O |t:2|
    SMILES:COC1=CC(=O)c2c(O)c(C(C)=O)c(C)cc2C1=O |t:2|
  • 2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins.2-Methoxystypandrone has anti-osteoclastogenic effect, could reflect the block of RANKL-induced association of TRAF6-TAK1 complexes with consequent decrease of IkappaB-mediated NF-kappaB and mitogen-activated protein kinases-mediated c-Fos activation pathways and suppression of NFATc1 and other gene expression, essential for bone resorption.
市场产品/服务共显示2个结果
  • 供应商
    TargetMolSC
    规格
    货期
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    -
    ¥ 3,090.00
    1
  • 供应商
    AnyMoleSC
    规格
    货期
    纯度
    -
    ¥ 3,250.00
    1

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