Name: Tanshindiol C
Rating: 5 (10 reviews)

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HIT ID:HIT213886598
Cas No:97465-71-9
常用名:Tanshindiol C
IUPAC:(6R,7R)-6,7-dihydroxy-1,6-dimethyl-6H,7H,8H,9H,10H,11H-phenanthro[1,2-b]furan-10,11-dione
IUPAC:(6R,7R)-6,7-dihydroxy-1,6-dimethyl-6H,7H,8H,9H,10H,11H-phenanthro[1,2-b]furan-10,11-dione
InChI key:RTKDBIDPGKCZJS-KZULUSFZSA-N

分子式:C18H16O5
分子量:312.321
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1coc-2c1C(=O)C(=O)c1c-2ccc2c1CC[C@@H](O)[C@]2(C)O
SMILES:Cc1coc-2c1C(=O)C(=O)c1c-2ccc2c1CC[C@@H](O)[C@]2(C)O

Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therapeutic intervention of atherosclerosis.It possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information for designing a new class of potent EZH2 inhibitors.

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