Name: Labd-13-ene-8,15-diol
Rating: 5 (10 reviews)

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HIT ID:HIT213887191
Cas No:10267-31-9
常用名:Labd-13-ene-8,15-diol
IUPAC:(1R,2R,4aS,8aS)-1-[(3E)-5-hydroxy-3-methylpent-3-en-1-yl]-2,5,5,8a-tetramethyl-decahydronaphthalen-2-ol
IUPAC:(1R,2R,4aS,8aS)-1-[(3E)-5-hydroxy-3-methylpent-3-en-1-yl]-2,5,5,8a-tetramethyl-decahydronaphthalen-2-ol
InChI key:LEOHDQKUMQKLMP-NUKBDRAPSA-N

分子式:C20H36O2
分子量:308.506
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:C\C(CC[C@H]1[C@](C)(O)CC[C@H]2C(C)(C)CCC[C@]12C)=C/CO
SMILES:C\C(CC[C@H]1[C@](C)(O)CC[C@H]2C(C)(C)CCC[C@]12C)=C/CO

13(E)-Labd-13-ene-8alpha,15-diol shows antiviral and anticancer activity, it shows strong anti-HRV2 and HRV3 activity with a 50% inhibitory concentration (IC50) of 2.68 and 0.87 microg/mL,respectively; it also exhibits antilung and antilaryngeal cancer activities against A549 and Hep2 cells.13(E)-Labd-13-ene-8α,15-diol inhibits the growth of the gram-positive bacteria (Staphylococcus aureus, Bacillus cereus and Listeria monocytogenes) and gram-negative bacteria (Vibrio parahaemolyticus, Escherichia coli and Salmonella enteritidis) with a range of minimum inhibitory concentration (MIC) values from 0.092 to 0.598 mg/mL and gram-negative bacteria are more sensitive to the compound (MIC, 0.092 mg/mL).

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