Name: Norcepharadione B
Rating: 5 (10 reviews)

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HIT ID:HIT214311491
Cas No:57576-41-7
常用名:Norcepharadione B
别名:鱼腥草
IUPAC:15,16-dimethoxy-10-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2(7),3,5,8,13,15-heptaene-11,12-dione
IUPAC:15,16-dimethoxy-10-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2(7),3,5,8,13,15-heptaene-11,12-dione
InChI key:BAGGDUOPTSQTHD-UHFFFAOYSA-N

分子式:C18H13NO4
分子量:307.305
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1cc2C(=O)C(=O)Nc3cc4ccccc4c(c1OC)c23
SMILES:COc1cc2C(=O)C(=O)Nc3cc4ccccc4c(c1OC)c23

Norcepharadione B shows good inhibitory activity against the replication of HSV-1, it also shows antimalarial activity with EC50 values of 7.5mug/ml. Norcepharadione B exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro. Norcepharadione B shows significant inhibitory effects on both ADP-induced and thrombin-induced platelet aggregation.

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