Name: Isoerysenegalensein E
Rating: 5 (10 reviews)

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HIT ID:HIT214311619
Cas No:478158-77-9
常用名:Isoerysenegalensein E
IUPAC:5,7-dihydroxy-6-(2-hydroxy-3-methylbut-3-en-1-yl)-3-(4-hydroxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
IUPAC:5,7-dihydroxy-6-(2-hydroxy-3-methylbut-3-en-1-yl)-3-(4-hydroxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one
InChI key:MHYBVRYBSLBMGT-UHFFFAOYSA-N

分子式:C25H26O6
分子量:422.477
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])c(-[#6]-[#6](-[#8])-[#6](-[#6])=[#6])c(-[#8])c2c1occ(-c1ccc(-[#8])cc1)c2=O
SMILES:[#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])c(-[#6]-[#6](-[#8])-[#6](-[#6])=[#6])c(-[#8])c2c1occ(-c1ccc(-[#8])cc1)c2=O

Isoerysenegalensein E shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor antagonist. It shows significant cytotoxicity against HL-60 cells, it induces apoptosis in HL-60 cells through activation of the caspase-9/caspase-3 pathway, which is triggered by mitochondrial dysfunction.

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