Name: Isololiolide
Rating: 5 (10 reviews)

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HIT ID:HIT214312624
Cas No:38274-00-9
常用名:Isololiolide
IUPAC:(6S,7aS)-6-hydroxy-4,4,7a-trimethyl-2,4,5,6,7,7a-hexahydro-1-benzofuran-2-one
IUPAC:(6S,7aS)-6-hydroxy-4,4,7a-trimethyl-2,4,5,6,7,7a-hexahydro-1-benzofuran-2-one
InChI key:XEVQXKKKAVVSMW-CPCISQLKSA-N

分子式:C11H16O3
分子量:196.246
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:C[C@]12C[C@@H](O)CC(C)(C)C1=CC(=O)O2 |c:10|
SMILES:C[C@]12C[C@@H](O)CC(C)(C)C1=CC(=O)O2 |c:10|

Isololiolide has phytotoxicity, it inhibited seedling growth of cress and barnyard grass. It also showed in vitro activity against both trypomastigote and intracellular amastigotes of Trypanosoma cruzi, with IC50 values of 32 μM and 40 μM, respectively. Isololiolide is an antioxidant response element (ARE) inducer, it has anti-inflammatory activity. It can exert a selective cytotoxic activity on hepatocarcinoma HepG2 cells as well as induce apoptosis through the modulation of apoptosis-related proteins.

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