Name: Destruxin B
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT214314753
Cas No:2503-26-6
常用名:Destruxin B
别名:黑僵菌素 B
IUPAC:(3S,6S,9S,16R,21aS)-3-[(2S)-butan-2-yl]-5,8,9-trimethyl-16-(2-methylpropyl)-6-(propan-2-yl)-icosahydropyrrolo[1,2-d]1-oxa-4,7,10,13,16-pentaazacyclononadecane-1,4,7,10,14,17-hexone
IUPAC:(3S,6S,9S,16R,21aS)-3-[(2S)-butan-2-yl]-5,8,9-trimethyl-16-(2-methylpropyl)-6-(propan-2-yl)-icosahydropyrrolo[1,2-d]1-oxa-4,7,10,13,16-pentaazacyclononadecane-1,4,7,10,14,17-hexone
InChI key:GNBHVMBELHWUIF-VTSYCQLTSA-N

分子式:C30H51N5O7
分子量:593.766
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12CCCN1C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@@]([H])(NC2=O)[C@@H](C)CC
SMILES:[H][C@@]12CCCN1C(=O)[C@@H](CC(C)C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@@]([H])(NC2=O)[C@@H](C)CC

Destruxin B is a cyclic peptide with insecticidal and anticancer activity isolated from the insect pathogenic fungus Metarhizium isopliae. Destruxin B induces apoptosis of human non-small cell lung cancer cells through the Bcl-2 family-dependent mitochondrial pathway. Destruxin B through caspase-mediated apoptosis can significantly activate caspase-3 in vitro and in vivo, reducing the proliferation of tumor cells.

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