Name: PAC
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HIT ID:HIT214314831
Cas No:2158322-33-7
Common Name:PAC
IUPAC:N-[(1S)-1-{[(1S)-4-(carbamoylamino)-1-[(4-{[4-(1-{4-[2-(2-{2-[2-({4-[(2S,3S)-8-cyano-5-[(2-methoxynaphthalen-1-yl)methyl]-2-methyl-3-[(2S)-2-(methylamino)propanamido]-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-carbonyl]phenyl}formamido)ethoxy]ethoxy}-N-methylacetamido)ethoxy]phenyl}-2-phenylbut-1-en-1-yl)phenoxy]methyl}phenyl)carbamoyl]butyl]carbamoyl}-2-methylpropyl]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide
IUPAC:N-[(1S)-1-{[(1S)-4-(carbamoylamino)-1-[(4-{[4-(1-{4-[2-(2-{2-[2-({4-[(2S,3S)-8-cyano-5-[(2-methoxynaphthalen-1-yl)methyl]-2-methyl-3-[(2S)-2-(methylamino)propanamido]-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-carbonyl]phenyl}formamido)ethoxy]ethoxy}-N-methylacetamido)ethoxy]phenyl}-2-phenylbut-1-en-1-yl)phenoxy]methyl}phenyl)carbamoyl]butyl]carbamoyl}-2-methylpropyl]-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide
InChIKey:AAGUYPGVVXJDLD-IIIOYBQMSA-N

Molecular Formula:C94H107N13O16
Molecular Weight:1674.965
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCC(=C(c1ccc(OCCN(C)C(=O)COCCOCCNC(=O)c2ccc(cc2)C(=O)N2[C@@H](C)[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4ccccc34)c3ccc(cc23)C#N)cc1)c1ccc(OCc2ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN3C(=O)C=CC3=O)C(C)C)cc2)cc1)c1ccccc1 |w:3.3,c:112|
SMILES:CCC(=C(c1ccc(OCCN(C)C(=O)COCCOCCNC(=O)c2ccc(cc2)C(=O)N2[C@@H](C)[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4ccccc34)c3ccc(cc23)C#N)cc1)c1ccc(OCc2ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN3C(=O)C=CC3=O)C(C)C)cc2)cc1)c1ccccc1 |w:3.3,c:112|

PAC (Proton-activated Chloride channel) is an acid-sensitive ion channel that mediates outwardly rectifying anion currents in response to extracellular acidification. Key data from the literature show that PAC knockout in mast cells reduces vesicular pH, increases endocytosis, and decreases exocytosis, while also elevating ROS levels and inducing C-shaped mitochondria. This channel also regulates lysosomal-mitochondrial colocalization and impairs mitochondrial respiration when absent. PAC is widely used in research on vesicular trafficking, organelle stress signaling, and cellular metabolic adaptation.

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