Name: Amuvatinib hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT214314910
Cas No:2344677-92-3;1055986-67-8
常用名:Amuvatinib hydrochloride
别名:MP470 hydrochloride, HPK 56 hydrochloride
别名:MP470 hydrochloride, HPK 56 hydrochloride
IUPAC:N-[(2H-1,3-benzodioxol-5-yl)methyl]-4-{8-oxa-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5,10,12-hexaen-6-yl}piperazine-1-carbothioamide hydrochloride
IUPAC:N-[(2H-1,3-benzodioxol-5-yl)methyl]-4-{8-oxa-3,5-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5,10,12-hexaen-6-yl}piperazine-1-carbothioamide hydrochloride
InChI key:IKQFRXPMBGQJGE-UHFFFAOYSA-N

分子式:C23H22ClN5O3S
分子量:483.97
氢键供体数 (HBD):1
氢键受体数 (HBA):5
LogP:4.432
SMILES:Cl.S=C(NCc1ccc2OCOc2c1)N1CCN(CC1)c1ncnc2c3ccccc3oc12
SMILES:Cl.S=C(NCc1ccc2OCOc2c1)N1CCN(CC1)c1ncnc2c3ccccc3oc12

Amuvatinib hydrochloride (MP470 hydrochloride) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret and is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair[1][2][3]. Antineoplastic activity[4].

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