Name: Zabofloxacin
Rating: 5 (10 reviews)

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HIT ID:HIT214315230
Cas No:219680-11-2
常用名:Zabofloxacin
别名:DW-224a Free base
IUPAC:1-cyclopropyl-6-fluoro-7-[8-(methoxyimino)-2,6-diazaspiro[3.4]octan-6-yl]-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
IUPAC:1-cyclopropyl-6-fluoro-7-[8-(methoxyimino)-2,6-diazaspiro[3.4]octan-6-yl]-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
InChI key:ZNPOCLHDJCAZAH-UHFFFAOYSA-N

分子式:C19H20FN5O4
分子量:401.398
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CON=C1CN(CC11CNC1)c1nc2n(cc(C(O)=O)c(=O)c2cc1F)C1CC1 |w:2.1|
SMILES:CON=C1CN(CC11CNC1)c1nc2n(cc(C(O)=O)c(=O)c2cc1F)C1CC1 |w:2.1|

Zabofloxacin is a potent and seletive bacterial type II and IV topoisomerases inhibitor, and has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia.

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