Name: K145
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214315257
Cas No:1309444-75-4
常用名:K145
IUPAC:3-(2-aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-1,3-thiazolidine-2,4-dione
IUPAC:3-(2-aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-1,3-thiazolidine-2,4-dione
InChI key:MPZXLTZVPUSTFY-UHFFFAOYSA-N

分子式:C18H24N2O3S
分子量:348.46
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCOc1ccc(CCC=C2SC(=O)N(CCN)C2=O)cc1 |w:11.10|
SMILES:CCCCOc1ccc(CCC=C2SC(=O)N(CCN)C2=O)cc1 |w:11.10|

K145 is inactive against SphK1 and other protein kinases. K145 induces cell apoptosis and has potently antitumor activity. K145 is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 μM and a Ki of 6.4 μM.

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