Name: (-)-Indolactam V
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT214315379
Cas No:90365-57-4
常用名:(-)-Indolactam V
别名:Indolactam V
IUPAC:(13S)-13-(hydroxymethyl)-9-methyl-10-(propan-2-yl)-3,9,12-triazatricyclo[6.6.1.0^{4,15}]pentadeca-1,4,6,8(15)-tetraen-11-one
IUPAC:(13S)-13-(hydroxymethyl)-9-methyl-10-(propan-2-yl)-3,9,12-triazatricyclo[6.6.1.0^{4,15}]pentadeca-1,4,6,8(15)-tetraen-11-one
InChI key:LUZOFMGZMUZSSK-HKALDPMFSA-N

分子式:C17H23N3O2
分子量:301.39
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)C1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23 |@@:1|
SMILES:CC(C)C1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23 |@@:1|

(-)-Indolactam V is a PKC activator (Kis: 3.36 nM, 1.03 μM for η-CRD2 , γ-CRD2). (-)-Indolactam V also has the Kds are 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B). It has antitumor activity.

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