Name: PNU-282987 S enantiomer hydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT214315419
Cas No:128311-08-0
常用名:PNU-282987 S enantiomer hydrochloride
常用名:PNU-282987 S enantiomer hydrochloride
别名:(S)-PNU-282987 HCl
IUPAC:N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide hydrochloride
IUPAC:N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide hydrochloride
InChI key:HSEQUIRZHDYOIX-BTQNPOSSSA-N

分子式:C14H18Cl2N2O
分子量:301.21
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.Clc1ccc(cc1)C(=O)N[C@@H]1CN2CCC1CC2 |THB:10:11:15.14:18.17|
SMILES:Cl.Clc1ccc(cc1)C(=O)N[C@@H]1CN2CCC1CC2 |THB:10:11:15.14:18.17|

(S)-PNU-282987 is the absolute stereochemistry form of PNU-282987. PNU 282987, a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs) with Ki of 26 nM for the rat receptor, has negligible activity against α1β1γδ and α3β4 nAChRs as well as a panel of monoamine, glutamate, muscarinic,and GABA receptors, except 5-HT3 with Ki of 930 nM.

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