Name: Camaric acid
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214315766
Cas No:146450-83-1
常用名:Camaric acid
IUPAC:(1S,2S,6S,10R,11S,14S,15R,18R,20S)-20-hydroxy-8,8,14,15,19,19-hexamethyl-10-{[(2Z)-2-methylbut-2-enoyl]oxy}-21-oxahexacyclo[18.2.2.0^{1,18}.0^{2,15}.0^{5,14}.0^{6,11}]tetracos-4-ene-11-carboxylic acid
IUPAC:(1S,2S,6S,10R,11S,14S,15R,18R,20S)-20-hydroxy-8,8,14,15,19,19-hexamethyl-10-{[(2Z)-2-methylbut-2-enoyl]oxy}-21-oxahexacyclo[18.2.2.0^{1,18}.0^{2,15}.0^{5,14}.0^{6,11}]tetracos-4-ene-11-carboxylic acid
InChI key:RSKOPEQHBSFOLQ-OTHZFUNLSA-N

分子式:C35H52O6
分子量:568.795
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12CC(C)(C)C[C@@H](OC(=O)C(\C)=C/C)[C@@]1(CC[C@]1(C)C2=CC[C@@]2([H])[C@@]1(C)CC[C@@]1([H])C(C)(C)[C@]3(O)CC[C@]21CO3)C(O)=O |t:22|
SMILES:[H][C@@]12CC(C)(C)C[C@@H](OC(=O)C(\C)=C/C)[C@@]1(CC[C@]1(C)C2=CC[C@@]2([H])[C@@]1(C)CC[C@@]1([H])C(C)(C)[C@]3(O)CC[C@]21CO3)C(O)=O |t:22|

Camaric acid shows antibacterial activity against Staphylococcus aureus and methicillin resistant S. aureus with IC50 values 8.74 and 8.09 uM, respectively, it also shows moderate antileishmanial activity and highly potent antitrypanosomal activity. Camaric acid possesses nematicidal activity. Camaric acid shows significant topical anti-inflammatory activity with IC50 value of 0.67 mg/ear in the assay of TPA mouse ear oedema model.

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