Name: Ganoderiol F
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214315921
Cas No:114567-47-4
常用名:Ganoderiol F
IUPAC:(1R,3aR,5aR,9aS,11aR)-1-[(2R)-7-hydroxy-6-(hydroxymethyl)hept-5-en-2-yl]-3a,6,6,9a,11a-pentamethyl-1H,2H,3H,3aH,5H,5aH,6H,7H,8H,9H,9aH,11H,11aH-cyclopenta[a]phenanthren-7-one
IUPAC:(1R,3aR,5aR,9aS,11aR)-1-[(2R)-7-hydroxy-6-(hydroxymethyl)hept-5-en-2-yl]-3a,6,6,9a,11a-pentamethyl-1H,2H,3H,3aH,5H,5aH,6H,7H,8H,9H,9aH,11H,11aH-cyclopenta[a]phenanthren-7-one
InChI key:JVGJXXNUVVQEIG-MCKXIFHVSA-N

分子式:C30H46O3
分子量:454.695
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]1([#6]-[#6][C@@]2([#6])[#6]-3=[#6]-[#6][C@@]4([H])C([#6])([#6])[#6](=O)-[#6]-[#6][C@]4([#6])[#6]-3=[#6]-[#6][C@]12[#6])[#6@H](-[#6])-[#6]-[#6]\[#6]=[#6](\[#6]-[#8])-[#6]-[#8] |c:22,t:6|
SMILES:[H][C@@]1([#6]-[#6][C@@]2([#6])[#6]-3=[#6]-[#6][C@@]4([H])C([#6])([#6])[#6](=O)-[#6]-[#6][C@]4([#6])[#6]-3=[#6]-[#6][C@]12[#6])[#6@H](-[#6])-[#6]-[#6]\[#6]=[#6](\[#6]-[#8])-[#6]-[#8] |c:22,t:6|

Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency virus-1 protease with IC(50) values of 20-40 microM. It induced HO-1 expression, activation of the mitogen-activated protein kinase EKR and up-regulation of cyclin-dependent kinase inhibitor p16 and suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO) production.

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