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  3. HIT214316066
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HIT214316066
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HIT214316066
  • HIT ID:HIT214316066
  • Cas No:24338-53-2
  • 常用名:Nagilactone C
  • IUPAC:(1S,2S,4R,5R,6R,9S,10R,17R)-5,10-dihydroxy-1,6-dimethyl-12-(propan-2-yl)-3,8,13-trioxapentacyclo[7.7.1.0^{2,4}.0^{6,17}.0^{11,16}]heptadeca-11,15-diene-7,14-dione
    IUPAC:(1S,2S,4R,5R,6R,9S,10R,17R)-5,10-dihydroxy-1,6-dimethyl-12-(propan-2-yl)-3,8,13-trioxapentacyclo[7.7.1.0^{2,4}.0^{6,17}.0^{11,16}]heptadeca-11,15-diene-7,14-dione
  • InChI key:DGNOPGIIPQKNHD-RSKPZANQSA-N
  • 分子式:C19H22O7
  • 分子量:362.378
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:[H][C@]12O[C@@]1([H])[C@]1(C)c3cc(=O)oc(C(C)C)c3[C@@H](O)[C@@]3([H])OC(=O)[C@@](C)([C@H]2O)[C@@]13[H]
    SMILES:[H][C@]12O[C@@]1([H])[C@]1(C)c3cc(=O)oc(C(C)C)c3[C@@H](O)[C@@]3([H])OC(=O)[C@@](C)([C@H]2O)[C@@]13[H]
  • Nagilactone C and phyllanthoside are novel protein synthesis inhibitors, they are specific for the eukaryotic translation apparatus, function in vivo and in vitro, and interfere with translation elongation. Nagilactone C shows high insecticidal activity against second-instar nymphs of Eocanthecona furcellata. Nagilactone C possesses potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 microg/ml, respectively.
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  • 供应商
    TargetMolSC
    规格
    货期
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    -
    ¥ 4,780.00
    1

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