Name: Physalin H
Rating: 5 (10 reviews)

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HIT ID:HIT214316102
Cas No:70241-09-7
常用名:Physalin H
IUPAC:(1R,2S,5S,8S,9S,14R,15R,17R,18R,21S,24R,26S,27R)-14-chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.1^{18,27}.0^{1,5}.0^{2,24}.0^{8,17}.0^{9,14}.0^{21,26}]nonacos-11-ene-4,10,22,29-tetrone
IUPAC:(1R,2S,5S,8S,9S,14R,15R,17R,18R,21S,24R,26S,27R)-14-chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.1^{18,27}.0^{1,5}.0^{2,24}.0^{8,17}.0^{9,14}.0^{21,26}]nonacos-11-ene-4,10,22,29-tetrone
InChI key:YNEPXUIPALKHAU-URURCIEQSA-N

分子式:C28H31ClO10
分子量:563
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@]12C(=O)[C@]34O[C@@]11[C@@](O)(CC[C@@]5([H])[C@@]3([H])C[C@@H](O)[C@@]3(Cl)CC=CC(=O)[C@]53C)C(=O)O[C@@]1(C)[C@H]1C[C@]2(C)[C@@]([H])(CO4)C(=O)O1 |c:23,THB:7:6:34.36.38.39:2|
SMILES:[H][C@]12C(=O)[C@]34O[C@@]11[C@@](O)(CC[C@@]5([H])[C@@]3([H])C[C@@H](O)[C@@]3(Cl)CC=CC(=O)[C@]53C)C(=O)O[C@@]1(C)[C@H]1C[C@]2(C)[C@@]([H])(CO4)C(=O)O1 |c:23,THB:7:6:34.36.38.39:2|

Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both in vitro and in vivo, and the immunosuppressive activity might be attributed to the suppression of T cell activation and proliferation, the modulation of Th1/Th2 cytokine balance and the induction of HO-1 in T cells. Physalin H shows significant in vitro leishmanicidal activities (0.92-19.4 microg/ml) against promastigotes of Leishmania major.Physalin H shows cytotoxic activity against a panel of human and murine cancer cell lines.

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