Name: Picoplatin
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214316386
Cas No:181630-15-9
常用名:Picoplatin
别名:NX-473, NX473, NX 473, AMD-473, AMD473, AMD 473
别名:NX-473, NX473, NX 473, AMD-473, AMD473, AMD 473
IUPAC:
IUPAC:
InChI key:ZXMANTQMUJWFSS-UHFFFAOYSA-N

分子式:C6H8Cl2N2Pt
分子量:374.13
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC1=[N](C=CC=C1)[Pt++]([NH])([Cl-])[Cl-] |c:3,5,t:1,^1:2,8,9,10|
SMILES:CC1=[N](C=CC=C1)[Pt++]([NH])([Cl-])[Cl-] |c:3,5,t:1,^1:2,8,9,10|

Picoplatin has a broad spectrum of antineoplastic activity and is designed to overcome platinum drug resistance. Picoplatin alkylates DNA, forming both intra- and inter-strand cross-linkages, resulting in the inhibition of DNA replication and transcription, and the induction of apoptosis.

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