Name: Gemcitabine monophosphate
Rating: 5 (10 reviews)

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HIT ID:HIT214316389
Cas No:116371-67-6
常用名:Gemcitabine monophosphate
别名:GemMP, Gemcitabine 5′-phosphate
IUPAC:{[(2R,3R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid
IUPAC:{[(2R,3R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy}phosphonic acid
InChI key:KNTREFQOVSMROS-QPPQHZFASA-N

分子式:C9H12F2N3O7P
分子量:343.18
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Nc1ccn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)C2(F)F)c(=O)n1
SMILES:Nc1ccn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)C2(F)F)c(=O)n1

Gemcitabine monophosphate is a novel HDAC inhibitor with broad-spectrum antitumor activity against solid (IC50: 30 to 300 nM) and hematological malignancies. Gemcitabine monophosphate was found to be a potent inhibitor of HDAC1 and -8 (class I) in vitro.

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