Name: 6-Bnz-cAMP sodium salt
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT214316438
Cas No:1135306-29-4
常用名:6-Bnz-cAMP sodium salt
IUPAC:N-{9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-hexahydro-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-9H-purin-6-yl}benzamide sodium
IUPAC:N-{9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxo-hexahydro-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-9H-purin-6-yl}benzamide sodium
InChI key:ZAWKSGYOANRJOW-FKVBDRBCSA-N

分子式:C17H16N5NaO7P
分子量:456.307
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[Na].[H][C@@]12COP(O)(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)n1cnc2c(NC(=O)c3ccccc3)ncnc12
SMILES:[Na].[H][C@@]12COP(O)(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)n1cnc2c(NC(=O)c3ccccc3)ncnc12

6-Bnz-cAMP is a PKA-selective activator. It regulates the PKA dependent signaling pathways. The proliferative signaling pathway which activated by the 6-Bnz-cAMP involves activation of the epidermal growth factor receptor and ERK1/2. Extending the duration of PKA-dependent ERK1/2 activation and converted cAMP from a proliferative into an anti-proliferative, neurite outgrowth- promoting signal.

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