Name: Wallichinine
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214316938
Cas No:125292-97-9
常用名:Wallichinine
别名:南藤素
IUPAC:4-[1-(3,4-dimethoxyphenyl)prop-1-en-2-yl]-4,5-dimethoxy-2-(prop-2-en-1-yl)cyclohexa-2,5-dien-1-one
IUPAC:4-[1-(3,4-dimethoxyphenyl)prop-1-en-2-yl]-4,5-dimethoxy-2-(prop-2-en-1-yl)cyclohexa-2,5-dien-1-one
InChI key:VKYZYTYFGUQBLS-UHFFFAOYSA-N

分子式:C22H26O5
分子量:370.445
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COC1=CC(=O)C(CC=C)=CC1(OC)C(C)=Cc1ccc(OC)c(OC)c1 |w:16.17,c:9,t:2|
SMILES:COC1=CC(=O)C(CC=C)=CC1(OC)C(C)=Cc1ccc(OC)c(OC)c1 |w:16.17,c:9,t:2|

Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF). Wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural products, wallichinine can significantly potentiate the effects of two ABCB1 substrates vincristine and doxorubicin on inhibition of growth, arrest of cell cycle and induction of apoptosis in ABCB1 overexpressing cancer cells, and the overexpression of ABCB1 in cancer cells is one of the main reasons of cancer multidrug resistance (MDR).

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