Name: Euphohelioscopin A
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214317014
Cas No:87064-61-7
常用名:Euphohelioscopin A
IUPAC:(1R,3Z,5R,7S,9R,10Z,12S,13S,14R)-1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0^{5,7}]pentadeca-3,10-dien-9-yl (2E,4Z)-octa-2,4-dienoate
IUPAC:(1R,3Z,5R,7S,9R,10Z,12S,13S,14R)-1-(acetyloxy)-13-hydroxy-3,6,6,10,14-pentamethyl-2-oxotricyclo[10.3.0.0^{5,7}]pentadeca-3,10-dien-9-yl (2E,4Z)-octa-2,4-dienoate
InChI key:LVWCGFQTAFKQBI-RZHLITKVSA-N

分子式:C30H42O6
分子量:498.66
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@]12C[C@@H](OC(=O)\C=C\C=C/CCC)\C(C)=C/[C@@]3([H])[C@@H](O)[C@H](C)C[C@]3(OC(C)=O)C(=O)\C(C)=C/[C@@]1([H])C2(C)C |c:15,33|
SMILES:[H][C@]12C[C@@H](OC(=O)\C=C\C=C/CCC)\C(C)=C/[C@@]3([H])[C@@H](O)[C@H](C)C[C@]3(OC(C)=O)C(=O)\C(C)=C/[C@@]1([H])C2(C)C |c:15,33|

Euphohelioscopin A, an activator of protein kinase C (PKC), it inhibits proliferation and induces differentiation of the myeloid leukemia cell lines THP-1 and HL-60. Euphohelioscopin A has anti-inflammary activity, it exhibits moderate inhibitory activity on the release of cytokine TNF-α (IC50 = 23.7 ± 1.7 uM), IL-6 (IC50 = 46.1 ± 1.1 uM) and chemokine MCP-1 (IC50 = 33.7 ± 3.8 uM) in lipopolysaccharide (LPS) induced RAW 264.7 macrophages without notable cytotoxicity (IC50 > 80 uM).

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