Name: Edgeworin
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

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HIT ID:HIT214317075
Cas No:120028-43-5
常用名:Edgeworin
IUPAC:7-hydroxy-3-[(2-oxo-2H-chromen-7-yl)oxy]-2H-chromen-2-one
IUPAC:7-hydroxy-3-[(2-oxo-2H-chromen-7-yl)oxy]-2H-chromen-2-one
InChI key:WNLKKLCKMRDNHF-UHFFFAOYSA-N

分子式:C18H10O6
分子量:322.272
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Oc1ccc2cc(Oc3ccc4ccc(=O)oc4c3)c(=O)oc2c1
SMILES:Oc1ccc2cc(Oc3ccc4ccc(=O)oc4c3)c(=O)oc2c1

Edgeworin is a DNA polymerase beta (pol beta) inhibitor, it inhibits both the lyase and polymerase activities of DNA polymerase beta; it can potentiate the inhibitory action of the anticancer drug bleomycin in cultured A549 cells via an inhibition of DNA repair synthesis.

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