Name: Thalidezine
Rating: 5 (10 reviews)

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类似物检索

HIT ID:HIT214317159
Cas No:18251-36-0
常用名:Thalidezine
IUPAC:(1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.2^{3,6}.1^{8,12}.1^{14,18}.0^{27,31}.0^{22,33}]hexatriaconta-3,5,8,10,12(34),18(33),19,21,24,26,31,35-dodecaen-19-ol
IUPAC:(1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.2^{3,6}.1^{8,12}.1^{14,18}.0^{27,31}.0^{22,33}]hexatriaconta-3,5,8,10,12(34),18(33),19,21,24,26,31,35-dodecaen-19-ol
InChI key:UYNHKOIUEXICNQ-VMPREFPWSA-N

分子式:C38H42N2O7
分子量:638.761
氢键供体数 (HBD):1
氢键受体数 (HBA):2
LogP:6.91
SMILES:[H][C@]12Cc3ccc(Oc4cc(C[C@]5([H])N(C)CCc6c(O)c(OC)c(OC)c(Oc7cc1c(CCN2C)cc7OC)c56)ccc4OC)cc3
SMILES:[H][C@]12Cc3ccc(Oc4cc(C[C@]5([H])N(C)CCc6c(O)c(OC)c(OC)c(Oc7cc1c(CCN2C)cc7OC)c56)ccc4OC)cc3

Thalidezine, a novel AMPK activator, eliminates apoptosis-resistant cancer cells through energy-mediated autophagic cell death, it can inhibit the growth of mouse L1210 cells in vitro. Thalidezine possesses antimicrobial activity against Mycobacterium smegmatis at concentrations of 100 microgram/ml or less.

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