Name: Mahanine
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214317211
Cas No:28360-49-8
常用名:Mahanine
IUPAC:(3R)-3,5-dimethyl-3-(4-methylpent-3-en-1-yl)-3H,11H-pyrano[3,2-a]carbazol-9-ol
IUPAC:(3R)-3,5-dimethyl-3-(4-methylpent-3-en-1-yl)-3H,11H-pyrano[3,2-a]carbazol-9-ol
InChI key:DWMBXHWBPZZCTN-HSZRJFAPSA-N

分子式:C23H25NO2
分子量:347.458
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)=CCC[C@@]1(C)Oc2c(C)cc3c([nH]c4cc(O)ccc34)c2C=C1 |wU:6.6,wD:6.5,c:27,(12.99,-4.96,;11.75,-4.04,;10.34,-4.65,;11.93,-2.51,;10.7,-1.59,;10.88,-.06,;9.65,.86,;10.77,1.91,;8.8,2.15,;7.26,2.06,;6.42,3.35,;7.11,4.72,;4.88,3.26,;4.19,1.88,;5.03,.59,;4.07,-.61,;2.63,-.06,;1.26,-.77,;-.04,.06,;-1.4,-.64,;.04,1.6,;1.41,2.31,;2.7,1.48,;6.57,.68,;7.42,-.61,;8.95,-.52,)|
SMILES:CC(C)=CCC[C@@]1(C)Oc2c(C)cc3c([nH]c4cc(O)ccc34)c2C=C1 |wU:6.6,wD:6.5,c:27,(12.99,-4.96,;11.75,-4.04,;10.34,-4.65,;11.93,-2.51,;10.7,-1.59,;10.88,-.06,;9.65,.86,;10.77,1.91,;8.8,2.15,;7.26,2.06,;6.42,3.35,;7.11,4.72,;4.88,3.26,;4.19,1.88,;5.03,.59,;4.07,-.61,;2.63,-.06,;1.26,-.77,;-.04,.06,;-1.4,-.64,;.04,1.6,;1.41,2.31,;2.7,1.48,;6.57,.68,;7.42,-.61,;8.95,-.52,)|

Mahanine has effects on the activation of the apoptotic pathway in human leukemia U937 cells, causes the mitochondrial membranes to lose their permeability, resulting in caspase-3 activation and apoptosis. Mahanine can reverse an epigenetically silenced gene, RASSF1A in prostate cancer cells by inhibiting DNMT activity that in turn down-regulates a key cell cycle regulator, cyclin D1, is an encouraging therapeutic choice for advanced prostatic cancer.

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