Name: MK-6169
Rating: 5 (10 reviews)

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结构编辑

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HIT ID:HIT214317525
Cas No:1620479-63-1
常用名:MK-6169
别名:MK6169
IUPAC:methyl N-{2-[(2S)-2-{5-[9-(5-cyclopropylthiophen-2-yl)-3-fluoro-5-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl}-8-oxa-10-azatetracyclo[8.7.0.0^{2,7}.0^{11,16}]heptadeca-1(17),2,4,6,11,13,15-heptaen-14-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-1-(2,2-dimethyloxan-4-yl)-2-oxoethyl}carbamate
IUPAC:methyl N-{2-[(2S)-2-{5-[9-(5-cyclopropylthiophen-2-yl)-3-fluoro-5-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl}-8-oxa-10-azatetracyclo[8.7.0.0^{2,7}.0^{11,16}]heptadeca-1(17),2,4,6,11,13,15-heptaen-14-yl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-1-(2,2-dimethyloxan-4-yl)-2-oxoethyl}carbamate
InChI key:YUFPCGICBPQXOJ-JUFMZOARSA-N

分子式:C54H62FN9O8S
分子量:1016.2
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1cc(F)c2-c3cc4cc(ccc4n3C(Oc2c1)c1ccc(s1)C1CC1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)C(NC(=O)OC)C1CCOC(C)(C)C1
SMILES:COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1cc(F)c2-c3cc4cc(ccc4n3C(Oc2c1)c1ccc(s1)C1CC1)-c1cnc([nH]1)[C@@H]1CCCN1C(=O)C(NC(=O)OC)C1CCOC(C)(C)C1

MK-6169 is an effective Pan-Genotype Hepatitis C Virus NS5A inhibitor. It also has Optimized Activity against Common Resistance-Associated Substitutions.

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