Name: Aminopterin N-hydroxysuccinimide ester
Rating: 5 (10 reviews)

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HIT ID:HIT214317733
Cas No:98457-88-6
常用名:Aminopterin N-hydroxysuccinimide ester
常用名:Aminopterin N-hydroxysuccinimide ester
别名:N-Hydroxysuccinimide aminopterin, Nhs-aminopterin
别名:N-Hydroxysuccinimide aminopterin, Nhs-aminopterin
IUPAC:(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]-5-[(2,5-dioxopyrrolidin-1-yl)oxy]-5-oxopentanoic acid
IUPAC:(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]-5-[(2,5-dioxopyrrolidin-1-yl)oxy]-5-oxopentanoic acid
InChI key:MYDJRYXFBSZFTR-HNNXBMFYSA-N

分子式:C24H25N9O7
分子量:551.52
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(=O)ON1C(=O)CCC1=O)C(O)=O
SMILES:CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(=O)ON1C(=O)CCC1=O)C(O)=O

Aminopterin N-hydroxysuccinimide ester is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effectively blocks tetrahydrofolate synthesis.

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