Name: L-NIL dihydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT214317798
Cas No:159190-45-1
常用名:L-NIL dihydrochloride
别名:N-Iminoethyl-L-lysine dihydrochloride, L-NIL HCl
别名:N-Iminoethyl-L-lysine dihydrochloride, L-NIL HCl
IUPAC:(2S)-2-amino-6-ethanimidamidohexanoic acid dihydrochloride
IUPAC:(2S)-2-amino-6-ethanimidamidohexanoic acid dihydrochloride
InChI key:OQIBCXRAFAHXMM-KLXURFKVSA-N

分子式:C8H19Cl2N3O2
分子量:260.16
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.Cl.CC(=N)NCCCC[C@H](N)C(O)=O
SMILES:Cl.Cl.CC(=N)NCCCC[C@H](N)C(O)=O

L-NIL HCl is a relatively selective iNOS inhibitor (IC50s: 0.4-3.3, 8-38, and 17-92 µM for iNOS, eNOS, and nNOS). L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major.

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