Name: NC1153
Rating: 5 (10 reviews)

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HIT ID:HIT214317884
Cas No:150661-91-9
常用名:NC1153
别名:NC-1153, NC 1153, CN-1153, CN1153, CN 1153
别名:NC-1153, NC 1153, CN-1153, CN1153, CN 1153
IUPAC:2,12-bis[(dimethylamino)methyl]cyclododecan-1-one dihydrochloride
IUPAC:2,12-bis[(dimethylamino)methyl]cyclododecan-1-one dihydrochloride
InChI key:GHMOOTNSJIQWGK-UHFFFAOYSA-N

分子式:C18H38Cl2N2O
分子量:369.42
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.Cl.CN(C)CC1CCCCCCCCCC(CN(C)C)C1=O
SMILES:Cl.Cl.CN(C)CC1CCCCCCCCCC(CN(C)C)C1=O

NC1153 is a blocker of IL-2-induced activation of JAK3 and its downstream substrates STAT5a/b. It promotes long-term allograft survival and sparing the recipient from multiple toxicities.

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