Name: Cenupatide
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214318051
Cas No:1006388-38-0
常用名:Cenupatide
别名:Ac-Arg-Aib-Arg-α(Me)Phe-NH2
IUPAC:(2S)-N-(1-{[(1S)-1-{[(1S)-1-benzyl-1-carbamoylethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-1-methylethyl)-5-carbamimidamido-2-acetamidopentanamide
IUPAC:(2S)-N-(1-{[(1S)-1-{[(1S)-1-benzyl-1-carbamoylethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-1-methylethyl)-5-carbamimidamido-2-acetamidopentanamide
InChI key:JDNFBDNDFFJJIB-JVAKCPTJSA-N

分子式:C28H47N11O5
分子量:617.756
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(=O)N[C@@H](CCCNC(N)=N)C(=O)NC(C)(C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@](C)(Cc1ccccc1)C(N)=O
SMILES:CC(=O)N[C@@H](CCCNC(N)=N)C(=O)NC(C)(C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@](C)(Cc1ccccc1)C(N)=O

Cenupatide is a urokinase plasminogen activator receptor (uPAR) inhibitor. Cenupatide inhibits uPAR binding to the formyl peptide receptors (FPRs) can improve kidney lesions in a rat model of STZ-induced diabetes. Cenupatide reverted STZ-induced up-regulation of uPA levels and activity, while uPAR on podocytes and (s)uPAR were unaffected. In glomeruli, Cenupatide inhibited FPR2 expression.

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